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Short (20-25 nucleotides in length), labeled probes are exposed to the non-fragmented target DNA, hybridization occurs with high specificity due to the short length of the probes and even a single base change will hinder hybridization.In this experiment, as in most molecular biology techniques, a control must be used to ensure successful experimentation.In molecular biology, procedures and technologies are continually being developed and older technologies abandoned.Between 1989 and February 2016, over 2,300 clinical trials had been conducted, more than half of them in phase I.

It should be noted that not all medical procedures that introduce alterations to a patient's genetic makeup can be considered gene therapy.Bone marrow transplantation and organ transplants in general have been found to introduce foreign DNA into patients.



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